Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.54 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1372846 | 0.90 | P2RX1 (0.49) | SCN9AMAPT | |
| Bromide SCHEMBL6522067 | 0.88 | P2RX1 (0.47) | SCN9AMAPT | |
| SCHEMBL4434283 | 0.85 | P2RX1 (0.45) | SCN9AMMP12ADAMTS5OPRL1MAPT | |
| SCHEMBL6524494 | 0.85 | P2RX1 (0.45) | SCN9AMMP12ADAMTS5OPRL1MAPT | |
| SCHEMBL10723893 | 0.85 | P2RX1 (0.55) | SCN9ACMA1MAPT | |
| SCHEMBL3211150 | 0.84 | AMPD2 (0.46) | SCN9A | |
| Bromide SCHEMBL4444724 | 0.84 | P2RX1 (0.44) | SCN9AMMP12ADAMTS5OPRL1MAPT | |
| SCHEMBL17377477 | 0.83 | SCN9A (0.63) | SCN9ACMA1MMP12ADAMTS5L3MBTL1 | |
| SCHEMBL12147169 | 0.83 | P2RX1 (0.47) | SCN9AMMP12ADAMTS5OPRL1 | |
| SCHEMBL1372776 | 0.83 | SCN9A (0.44) | SCN9ACASP3LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529100-B1 | INDOLINOSPIROBENZOPYRAN DERIVATIVE | OTSUKA KAGAKU KK (JP) | 1998-11-11 | — | — | EP | disclosed |
| EP-0530369-B1 | CRYSTAL COMPRISING INDOLINOSPIROBENZOTHIOPYRAN DERIVATIVE AND RING-OPENING ISOMER THEREOF | OTSUKA KAGAKU KK (JP) | 1997-02-05 | — | — | EP | disclosed |
| US-5403702-A | Crystals consisting of an indolinospirobenzopyran derivative | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1995-04-04 | — | — | US | disclosed |
| US-5320784-A | Crystal comprising an indolinospirobenzothiopyran derivative and its ring opened isomer | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1994-06-14 | — | — | US | disclosed |
| EP-0530369-A1 | CRYSTAL COMPRISING INDOLINOSPIROBENZOTHIOPYRAN DERIVATIVE AND RING-OPENING ISOMER THEREOF | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1993-03-10 | — | — | EP | disclosed |
| EP-0529100-A1 | INDOLINOSPIROBENZOPYRAN DERIVATIVE | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1993-03-03 | — | — | EP | disclosed |