Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.49 |
| ▸ | USP7 | Q93009 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570559 | 0.85 | FOLH1 (0.57) | FOLH1HSD17B10 | |
| SCHEMBL4530811 | 0.85 | MKNK1 (0.53) | MKNK1MKNK2USP7PARP10PLA2G10 | |
| SCHEMBL4434804 | 0.84 | BAZ2B (0.47) | FOLH1CREBBPPARP1 | |
| SCHEMBL13821807 | 0.83 | RAB9A (0.46) | FOLH1MAPTTDP1L3MBTL1CA12 | |
| Bicarbonate SCHEMBL28365018 | 0.80 | FOLH1 (0.50) | FOLH1PLA2G2A | |
| SCHEMBL27588092 | 0.79 | PLA2G10 (0.43) | PARP10PLA2G10PLA2G2APOLBCYP3A4 | |
| Acetic Acid SCHEMBL28455812 | 0.78 | FOLH1 (0.49) | FOLH1PLA2G2A | |
| SCHEMBL473270 | 0.77 | PDCD1 (0.50) | FOLH1PLA2G2A | |
| SCHEMBL27618792 | 0.75 | PDCD1 (0.48) | FOLH1PLA2G2A | |
| SCHEMBL11382363 | 0.75 | PDCD1 (0.48) | FOLH1PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121621-A1 | LXR AND FXR MODULATORS | Exelixis, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008073825-A1 | LXR AND FXR MODULATORS | EXELIXIS, INC. (US) | 2008-06-19 | — | — | WO | disclosed |