Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TOP1 | P11387 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20304 | 0.96 | HTR7 (0.40) | SMN1; SMN2HPGDRAB9ANPC1TP53 | |
| SCHEMBL28439942 | 0.96 | HTR7 (0.40) | SMN1; SMN2HPGDRAB9ANPC1TP53 | |
| SCHEMBL30068977 | 0.94 | HTR7 (0.39) | SMN1; SMN2HPGDRAB9ANPC1TP53 | |
| SCHEMBL5502813 | 0.94 | HTR7 (0.39) | SMN1; SMN2HPGDRAB9ANPC1TP53 | |
| SCHEMBL30181989 | 0.94 | HTR7 (0.39) | SMN1; SMN2HPGDRAB9ANPC1TP53 | |
| Hydrochloric Acid SCHEMBL29391428 | 0.94 | HTR7 (0.39) | SMN1; SMN2HPGDRAB9ANPC1TP53 | |
| SCHEMBL29841836 | 0.94 | HPGD (0.40) | SMN1; SMN2HPGDRAB9ANPC1TP53 | |
| SCHEMBL4216711 | 0.94 | HTR7 (0.39) | SMN1; SMN2HPGDRAB9ANPC1TP53 | |
| SCHEMBL26657101 | 0.94 | HTR7 (0.39) | SMN1; SMN2HPGDRAB9ANPC1TP53 | |
| SCHEMBL3023273 | 0.94 | HPGD (0.40) | SMN1; SMN2HPGDRAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105505-A1 | PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES | LONZA AG (CH) | 2009-04-23 | — | — | US | disclosed |
| EP-1778704-B1 | PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES | LONZA AG (CH) | 2008-11-26 | — | — | EP | disclosed |
| EP-1778704-A1 | PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES | LONZA AG (CH) | 2007-05-02 | — | — | EP | disclosed |
| EP-1761548-A1 | PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES | LONZA AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006002729-A1 | PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES | LONZA AG (CH) | 2006-01-12 | — | — | WO | disclosed |
| WO-2006002731-A1 | PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES | LONZA AG (CH) | 2006-01-12 | — | — | WO | disclosed |
| EP-1609795-A1 | Process for the preparation of asymmetrically substituted biaryldiphosphines | Lonza AG (CH) | 2005-12-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105505-A1 | PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES | C1S, KMO, C1R | SMN1; SMN2 4476/4885HPGD 4530/4885RAB9A 1212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.