Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | S100B | P04271 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30063002 | 1.00 | ALDH1A1 (0.64) | ALDH1A1KDM4ELMNAPKML3MBTL1 | |
| SCHEMBL28338201 | 0.89 | ALDH1A1 (0.78) | ALDH1A1KDM4ELMNAPKML3MBTL1 | |
| SCHEMBL20495516 | 0.88 | ALDH1A1 (0.49) | ALDH1A1KDM4ELMNAPKML3MBTL1 | |
| SCHEMBL1048147 | 0.84 | KDM4E (0.68) | ALDH1A1KDM4ELMNAPKML3MBTL1 | |
| SCHEMBL330331 | 0.82 | ALDH1A1 (0.73) | ALDH1A1KDM4ELMNAPKML3MBTL1 | |
| SCHEMBL5494223 | 0.82 | ALDH1A1 (0.73) | ALDH1A1KDM4ELMNAPKML3MBTL1 | |
| SCHEMBL16993892 | 0.81 | ALDH1A1 (0.69) | ALDH1A1KDM4ELMNAL3MBTL1POLB | |
| SCHEMBL997022 | 0.81 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAPKML3MBTL1 | |
| SCHEMBL1110554 | 0.81 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAPKML3MBTL1 | |
| SCHEMBL1110535 | 0.81 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAPKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |