Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28499917 | 0.87 | HTR2C (0.50) | HTR2CHTR2ADRD2TRPM8HTR6 | |
| SCHEMBL537759 | 0.80 | HTR2C (0.50) | HTR2CTRPM8ADRA2AHTR2BOPRD1 | |
| Hydrochloric Acid SCHEMBL3708253 | 0.79 | HTR2C (0.49) | HTR2CTRPM8ADRA2AHTR2BOPRD1 | |
| SCHEMBL15075059 | 0.76 | HTR2C (0.47) | HTR2CHTR2ADRD2TRPM8ADRA2A | |
| SCHEMBL20270585 | 0.74 | HTR2C (0.33) | HTR2CHTR2ADRD2 | |
| SCHEMBL12482015 | 0.74 | TRPM8 (0.52) | HTR2CTRPM8HTR6 | |
| SCHEMBL30538343 | 0.74 | SIGMAR1 (0.53) | HTR2CHTR2ADRD2TRPM8HTR2B | |
| SCHEMBL471621 | 0.74 | SIGMAR1 (0.53) | HTR2CHTR2ADRD2TRPM8HTR2B | |
| SCHEMBL27454334 | 0.73 | HTR2C (0.42) | HTR2CHTR2ADRD2TRPM8HTR6 | |
| SCHEMBL15075100 | 0.73 | HTR2C (0.45) | HTR2CHTR2ADRD2TRPM8ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009037542-A2 | SPIROCYCLIC COMPOUNDS AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009037542-A2 | SPIROCYCLIC COMPOUNDS AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-03-26 | — | — | WO | disclosed |