SCHEMBL4445231

SCHEMBL4445231

C=C1CC(=O)N(c2cc(N3C(=O)C=CC3=O)c(C)cc2C)C1=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 5/20 0.39
MAPT P10636 4/20 0.36
CCR6 P51684 4/20 0.36
HSP90AA1 P07900 4/20 0.36
HPGD P15428 3/20 0.36
ALDH1A1 P00352 3/20 0.36
TDP1 Q9NUW8 2/20 0.36
PKM P14618 2/20 0.36
NPSR1 Q6W5P4 2/20 0.36
HTT P42858 1/20 0.36
NLRP1 Q9C000 1/20 0.36
KMT2A Q03164 4/20 0.34
CASP3 P42574 1/20 0.34
CASP6 P55212 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
SENP6 Q9GZR1 1/20 0.34
MEN1 O00255 3/20 0.33
ALOX15 P16050 1/20 0.33
ALOX12 P18054 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4443314 0.82 MGLL (0.41) MGLLMAPTCCR6HSP90AA1HPGD
SCHEMBL4443144 0.82 MGLL (0.40) MGLLMAPTCCR6HSP90AA1HPGD
SCHEMBL4443401 0.80 MGLL (0.45) MGLLMAPTCCR6HSP90AA1ALDH1A1
SCHEMBL5078134 0.79 MGLL (0.56) MGLLMAPTCCR6HSP90AA1HPGD
SCHEMBL4443452 0.79 TLR9 (0.59) MGLLMAPTCCR6HSP90AA1HPGD
SCHEMBL4448542 0.75 TLR9 (0.44) MGLLMAPTCCR6HSP90AA1HPGD
SCHEMBL4457947 0.75 TLR9 (0.44) MGLLMAPTCCR6HSP90AA1HPGD
SCHEMBL9418756 0.73 MGLL (0.58) MGLLMAPTCCR6HSP90AA1HPGD
SCHEMBL4443303 0.71 MGLL (0.56) MGLLCCR6HSP90AA1HPGDALDH1A1
SCHEMBL2229875 0.70 MGLL (0.43) MGLLMAPTCCR6HSP90AA1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1863871-B1 RUBBER COMPOSITION COMPRISING AN ITACONIMIDO-MALEIMIDE MICHELIN SOC TECH (FR) 2009-08-12 EP claimed
US-7557151-B2 Rubber composition comprising an itaconimidomaleimide MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2009-07-07 US claimed
US-20090036579-A1 Rubber Composition Comprising an Itaconimidomaleimide MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2009-02-05 US claimed
EP-1863871-A1 RUBBER COMPOSITION COMPRISING AN ITACONIMIDO-MALEIMIDE Societe de Technologie Michelin STM (FR) 2007-12-12 EP claimed
WO-2006099985-A1 RUBBER COMPOSITION COMPRISING AN ITACONIMIDO-MALEIMIDE SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2006-09-28 WO claimed
EP-1863871-B1 RUBBER COMPOSITION COMPRISING AN ITACONIMIDO-MALEIMIDE MICHELIN SOC TECH (FR) 2009-08-12 EP disclosed
US-7557151-B2 Rubber composition comprising an itaconimidomaleimide MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2009-07-07 US disclosed
US-20090036579-A1 Rubber Composition Comprising an Itaconimidomaleimide MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2009-02-05 US disclosed
EP-1863871-A1 RUBBER COMPOSITION COMPRISING AN ITACONIMIDO-MALEIMIDE Societe de Technologie Michelin STM (FR) 2007-12-12 EP disclosed
WO-2006099985-A1 RUBBER COMPOSITION COMPRISING AN ITACONIMIDO-MALEIMIDE SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2006-09-28 WO disclosed