Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445860 | 1.00 | NR1D1 (0.44) | NR1D1PPARGPPARA | |
| SCHEMBL3153356 | 0.85 | NR1D1 (0.49) | NR1D1 | |
| SCHEMBL2540092 | 0.84 | NR1D1 (0.38) | NR1D1PPARGPPARA | |
| SCHEMBL2540093 | 0.84 | NR1D1 (0.39) | NR1D1 | |
| SCHEMBL2540085 | 0.84 | NR1D1 (0.39) | NR1D1 | |
| SCHEMBL4563902 | 0.84 | AAK1 (0.43) | — | |
| SCHEMBL18203970 | 0.84 | AAK1 (0.43) | — | |
| SCHEMBL560618 | 0.84 | AAK1 (0.39) | — | |
| SCHEMBL560617 | 0.84 | AAK1 (0.39) | — | |
| SCHEMBL18203971 | 0.84 | AAK1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013175-B9 | p38 MAP KINASE INHIBITORS | MACROPHAGE PHARMA LTD (GB) | 2020-11-11 | — | — | EP | disclosed |
| EP-2013175-B1 | p38 MAP KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2016-11-09 | — | — | EP | disclosed |
| CN-102942520-A | P38 map kinase inhibitors | CHROMA THERAPEUTICS LTD | 2013-02-27 | — | — | CN | disclosed |
| CN-101437799-B | P38map kinase inhibitors | CHROMA THERAPEUTICS LTD | 2012-12-26 | — | — | CN | disclosed |
| CN-101437799-A | P38MAP kinase inhibitors | CHROMA THERAPEUTICS LTD (GB) | 2009-05-20 | — | — | CN | disclosed |
| EP-2013175-A1 | p38 MAP KINASE INHIBITORS | Chroma Therapeutics Limited (GB) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007129040-A1 | p38 MAP KINASE INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2007-11-15 | — | — | WO | disclosed |