Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PPID | Q08752 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18203971 | 1.00 | AAK1 (0.43) | AAK1F7HDAC3HDAC1HDAC2 | |
| SCHEMBL18203970 | 1.00 | AAK1 (0.43) | AAK1F7HDAC3HDAC1HDAC2 | |
| SCHEMBL560617 | 0.88 | AAK1 (0.39) | AAK1F7HDAC3HDAC1HDAC2 | |
| SCHEMBL560618 | 0.88 | AAK1 (0.39) | AAK1F7HDAC3HDAC1HDAC2 | |
| SCHEMBL4564346 | 0.84 | ALDH1A1 (0.42) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL4564347 | 0.84 | ALDH1A1 (0.42) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL4445852 | 0.84 | NR1D1 (0.44) | — | |
| SCHEMBL4445860 | 0.84 | NR1D1 (0.44) | — | |
| SCHEMBL3143341 | 0.83 | MEN1 (0.42) | AAK1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL2544106 | 0.82 | AAK1 (0.39) | AAK1RENMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013175-A1 | p38 MAP KINASE INHIBITORS | Chroma Therapeutics Limited (GB) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007129040-A1 | p38 MAP KINASE INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2007-11-15 | — | — | WO | disclosed |