SCHEMBL4445857

SCHEMBL4445857

CCCc1nc(C)n(CC2(O)CCOCC2)c(=O)c1Cc1ccc(-c2ccccc2)c(-c2noc(=O)[nH]2)c1

nearest known ligand 0.52

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 3/20 0.52
SLC33A1 O00400 15/20 0.48
PPARG P37231 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1895756 0.92 SLC33A1 (0.57) AGTR1SLC33A1
SCHEMBL4306343 0.81 PPARG (0.48) AGTR1SLC33A1PPARG
SCHEMBL12348642 0.78 PPARG (0.40) AGTR1SLC33A1PPARG
SCHEMBL4017161 0.77 PPARG (0.52) AGTR1PPARG
SCHEMBL4016512 0.77 PPARG (0.48) AGTR1SLC33A1PPARG
SCHEMBL4306427 0.75 SLC33A1 (0.50) SLC33A1PPARG
SCHEMBL1887468 0.75 SLC33A1 (0.59) AGTR1SLC33A1PPARG
SCHEMBL4167619 0.75 AGTR1 (0.49) AGTR1PPARG
SCHEMBL4306886 0.75 AGTR1 (0.48) AGTR1SLC33A1PPARG
SCHEMBL3487690 0.75 SLC33A1 (0.43) SLC33A1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009133970-A1 CRYSTALLINE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-11-05 WO disclosed