Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10513383 | 0.88 | KDM4E (0.78) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL15230641 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL31528532 | 0.82 | KDM4E (0.69) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL31716981 | 0.81 | KDM4E (0.68) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL9570185 | 0.81 | KDM4E (0.68) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL9597293 | 0.81 | KDM4E (0.68) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL30024824 | 0.81 | ALDH1A1 (0.68) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL21301424 | 0.80 | KDM4E (0.66) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL12329335 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL31716611 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1POLBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140194477-A1 | KINASE PROTEIN BINDING INHIBITORS | ROSWELL PARK CANCER INSTITUTE (US) | 2014-07-10 | — | — | US | disclosed |
| US-8404669-B2 | Kinase modulating compounds and uses thereof for treatment of cancer | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-03-26 | — | — | US | disclosed |
| WO-2012139001-A2 | KINASE PROTEIN BINDING INHIBITORS | ROSWELL PARK CANCER INSTITUTE (US) | 2012-10-11 | — | — | WO | disclosed |
| EP-2136829-A1 | KINASE PROTEIN BINDING INHIBITORS | University Of Florida Research Foundation (US) | 2009-12-30 | — | — | EP | disclosed |
| US-20090239850-A1 | Kinase protein binding inhibitors | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2009-09-24 | — | — | US | disclosed |
| WO-2008115443-A1 | KINASE PROTEIN BINDING INHIBITORS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2008-09-25 | — | — | WO | disclosed |
| EP-0370381-B1 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-4988698-A | Cardiovascular disorders, hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-29 | — | — | US | disclosed |
| EP-0370381-A2 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-30 | — | — | EP | disclosed |