Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.49 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | KDM5C | P41229 | 1/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.49 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1329694 | 0.99 | XDH (0.54) | XDHKMOKDM4CKDM4EKDM6B | |
| SCHEMBL1329554 | 0.97 | XDH (0.53) | XDHKMOKDM4CKDM4EKDM6B | |
| SCHEMBL1331331 | 0.89 | XDH (0.55) | XDHKMOKDM4C | |
| SCHEMBL3387162 | 0.89 | KMO (0.56) | XDHKMOKDM4C | |
| SCHEMBL1329552 | 0.88 | XDH (0.45) | XDHKMOKDM4CKDM4AKDM5C | |
| SCHEMBL3383379 | 0.86 | XDH (0.55) | XDHKMOKDM4CKDM4EKDM6B | |
| SCHEMBL1330582 | 0.86 | KDM4E (0.52) | XDHKDM4CKDM4EKDM6BKDM5C | |
| SCHEMBL10092841 | 0.84 | XDH (0.57) | XDHKMOKDM4CKDM4E | |
| SCHEMBL1330401 | 0.83 | XDH (0.50) | XDHKMOKDM4CKDM4EKDM6B | |
| SCHEMBL1331700 | 0.82 | KDM4C (0.52) | XDHKMOKDM4CKDM4EKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426453-B2 | Treatment of a stomach or small intestine ulcer with 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid | ASTELLAS PHARMA INC. (JP) | 2013-04-23 | — | — | US | disclosed |
| EP-1992361-B1 | Remedy or preventive for digestive ulcer | ASTELLAS PHARMA INC (JP) | 2012-05-02 | — | — | EP | disclosed |
| EP-1992361-A1 | REMEDY OR PREVENTIVE FOR DIGESTIVE ULCER | Astellas Pharma Inc. (JP) | 2008-11-19 | — | — | EP | disclosed |