Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CDC42 | P60953 | 1/20 | 0.40 |
| ▸ | RAC1 | P63000 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11675022 | 0.87 | BCHE (0.54) | ABCB11BCHETYRACHEHTT | |
| SCHEMBL7128925 | 0.80 | ABCB11 (0.52) | ABCB11L3MBTL1TSHRCYP1A2CYP2C9 | |
| SCHEMBL11356828 | 0.80 | HTT (0.41) | BCHETYRACHEHTTCYP1A2 | |
| SCHEMBL4661046 | 0.78 | TYR (0.56) | ABCB11BCHETYRACHESMN1; SMN2 | |
| SCHEMBL11348098 | 0.76 | HTT (0.41) | BCHETYRACHEHTTCYP1A2 | |
| SCHEMBL11407371 | 0.76 | HTT (0.41) | BCHETYRACHEHTTCYP1A2 | |
| SCHEMBL3941057 | 0.76 | ABCB11 (0.49) | ABCB11L3MBTL1SMN1; SMN2TSHRCYP1A2 | |
| SCHEMBL15617596 | 0.75 | ACP3 (0.58) | ABCB11HTTL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL9711999 | 0.73 | ABCB11 (0.52) | ABCB11L3MBTL1TSHRCYP1A2CYP2C9 | |
| SCHEMBL19984896 | 0.73 | TDP1 (0.51) | ABCB11L3MBTL1TSHRCYP2C9GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074102-A1 | 2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008043567-A1 | 2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2008-04-17 | — | — | WO | disclosed |