Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 14/20 | 0.49 |
| ▸ | F13A1 | P00488 | 11/20 | 0.49 |
| ▸ | TGM1 | P22735 | 8/20 | 0.49 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14837774 | 0.80 | TGM2 (0.48) | TGM2F13A1TGM1TGM3GPR119 | |
| SCHEMBL16990306 | 0.76 | TGM2 (0.52) | TGM2F13A1TGM1TGM3GPR119 | |
| SCHEMBL11945569 | 0.75 | TGM2 (0.49) | TGM2F13A1TGM1TGM3GPR119 | |
| SCHEMBL1180685 | 0.74 | TGM2 (0.50) | TGM2F13A1TGM1LMNAMAPT | |
| SCHEMBL14837788 | 0.74 | TGM2 (0.47) | TGM2F13A1TGM1TGM3GPR119 | |
| SCHEMBL18410584 | 0.73 | TGM2 (0.65) | TGM2F13A1TGM1ALDH1A1MEN1 | |
| SCHEMBL26065927 | 0.72 | TGM2 (0.52) | TGM2F13A1TGM1TGM3ALDH1A1 | |
| SCHEMBL1955697 | 0.72 | ALDH1A1 (0.62) | TGM2F13A1TGM1ALDH1A1LMNA | |
| SCHEMBL2252120 | 0.71 | TGM2 (0.63) | TGM2F13A1TGM1GPR119ALDH1A1 | |
| SCHEMBL4892640 | 0.71 | TGM2 (0.53) | TGM2F13A1TGM1TGM3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114949-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |