Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824388 | 0.93 | SMN1; SMN2 (0.64) | KMT2ANPSR1MAPTMAPK1RAB9A | |
| SCHEMBL8338154 | 0.88 | SMN1; SMN2 (0.71) | KMT2ANPSR1MAPTMAPK1RAB9A | |
| SCHEMBL13356437 | 0.88 | SMN1; SMN2 (0.62) | KMT2AMAPK1LMNASLC6A3SMN1; SMN2 | |
| SCHEMBL28045612 | 0.88 | AKR1C3 (0.62) | KMT2AMAPTMAPK1RAB9AMEN1 | |
| SCHEMBL7101319 | 0.86 | MAPT (0.64) | KMT2ANPSR1MAPTMAPK1RAB9A | |
| SCHEMBL9851196 | 0.85 | KMT2A (0.70) | KMT2ANPSR1MAPTMAPK1RAB9A | |
| SCHEMBL30045516 | 0.85 | GAA (0.60) | KMT2ALMNASLC6A3SMN1; SMN2ALDH1A1 | |
| SCHEMBL29011848 | 0.85 | GAA (0.60) | KMT2ALMNASLC6A3SMN1; SMN2ALDH1A1 | |
| SCHEMBL27704684 | 0.83 | ALDH1A1 (0.59) | KMT2ANPSR1MAPTMAPK1RAB9A | |
| SCHEMBL27761886 | 0.83 | AKR1C3 (0.61) | KMT2AMAPTMEN1LMNASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090072206-A1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS | JOHNSON & JOHNSON VISION CARE, INC. | 2009-03-19 | — | — | US | disclosed |
| EP-1869140-A1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS | Johnson and Johnson Vision Care, Inc. (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006110513-A1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2006-10-19 | — | — | WO | disclosed |
| US-20060226402-A1 | Ophthalmic devices comprising photochromic materials having extended PI-conjugated systems | KIM BEON-KYU | 2006-10-12 | — | — | US | disclosed |