Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ELANE | P08246 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377105 | 0.78 | ALOX15 (0.39) | ALOX15SMN1; SMN2 | |
| SCHEMBL3332762 | 0.75 | RAB9A (0.42) | HIF1AEPAS1ABCG2KDM4EKMT2A | |
| SCHEMBL12288144 | 0.72 | HIF1A (0.44) | HIF1AEPAS1ABCG2KDM4EKMT2A | |
| SCHEMBL6968831 | 0.67 | KMT2A (0.41) | KMT2AALDH1A1HSD17B10MEN1MAPT | |
| SCHEMBL19182829 | 0.67 | POLB (0.37) | KDM4EALDH1A1HSD17B10MAPTPOLB | |
| SCHEMBL4441103 | 0.67 | PTPN1 (0.34) | KDM4EKMT2AALDH1A1HSD17B10POLB | |
| SCHEMBL10509864 | 0.66 | PDE5A (0.39) | KDM4EKMT2AALDH1A1HSD17B10MEN1 | |
| SCHEMBL17200012 | 0.66 | PPARA (0.41) | KDM4EALDH1A1HSD17B10MAPTPOLB | |
| SCHEMBL10506675 | 0.65 | PDE5A (0.36) | KDM4EKMT2AALDH1A1HSD17B10MEN1 | |
| SCHEMBL31266381 | 0.65 | MAPT (0.45) | KDM4EKMT2AALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120923-B1 | USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | SANOFI SA (FR) | 2012-07-18 | — | — | EP | disclosed |
| EP-2120923-A1 | USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008086949-A1 | USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | SANOFI-AVENTIS (FR) | 2008-07-24 | — | — | WO | disclosed |