Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PTPRC | P08575 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29460197 | 0.77 | CES1 (0.83) | CES1ALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL380656 | 0.74 | CES1 (1.00) | CES1ALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL27944321 | 0.72 | ADORA2A (0.42) | CES1ALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL70455 | 0.69 | CES1 (0.56) | CES1ALDH1A1HPGDHSD17B10CYP3A4 | |
| SCHEMBL16107418 | 0.68 | ALDH1A1 (0.87) | ALDH1A1HPGDHSD17B10TDP1CYP3A4 | |
| SCHEMBL14876644 | 0.68 | ALDH1A1 (0.87) | ALDH1A1HPGDHSD17B10TDP1CYP3A4 | |
| SCHEMBL29365003 | 0.68 | ALDH1A1 (1.00) | ALDH1A1HPGDHSD17B10TDP1CYP3A4 | |
| SCHEMBL27912581 | 0.68 | ALDH1A1 (1.00) | ALDH1A1HPGDHSD17B10TDP1CYP3A4 | |
| SCHEMBL48843 | 0.68 | ALDH1A1 (1.00) | ALDH1A1HPGDHSD17B10TDP1CYP3A4 | |
| SCHEMBL4948969 | 0.68 | CES1 (0.42) | CES1ALDH1A1HPGDHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755574-A4 | PTEN INHIBITORS | SEMAFORE PHARMACEUTICALS INC (US) | 2009-05-13 | — | — | EP | disclosed |
| US-20070203098-A1 | Pten Inhibitors | SEMAFORE PHARMACEUTICALS, INC. (US) | 2007-08-30 | — | — | US | disclosed |
| EP-1755574-A2 | PTEN INHIBITORS | Semafore Pharmaceuticals, Inc. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005097119-A2 | PTEN INHIBITORS | SEMAFORE PHARMACEUTICALS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203098-A1 | Pten Inhibitors | PTEN, MTMR1, PTPRJ | CES1 1635/4885ALDH1A1 2982/4885HPGD 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.