Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPOX | P50336 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 14/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016337 | 0.87 | CCR1 (0.37) | PPOXCCR1ALDH1A1LMNATP53 | |
| SCHEMBL3469130 | 0.85 | CCR1 (0.46) | CCR1 | |
| SCHEMBL3638427 | 0.83 | CCR1 (0.35) | PPOXCCR1ROCK2PRKG1ALDH1A1 | |
| SCHEMBL4013895 | 0.81 | PPOX (0.34) | PPOXCCR1ROCK2PRKG1ALDH1A1 | |
| SCHEMBL3632434 | 0.79 | PPOX (0.43) | PPOXCCR1ROCK2PRKG1ALDH1A1 | |
| SCHEMBL3726336 | 0.79 | PPOX (0.43) | PPOXCCR1ROCK2PRKG1ALDH1A1 | |
| SCHEMBL4020093 | 0.79 | CCR1 (0.43) | CCR1 | |
| SCHEMBL3632485 | 0.77 | PPOX (0.35) | PPOXCCR1ROCK2PRKG1ALDH1A1 | |
| SCHEMBL3640517 | 0.77 | ROCK2 (0.38) | PPOXCCR1ROCK2PRKG1ALDH1A1 | |
| SCHEMBL3633830 | 0.77 | ROCK2 (0.39) | PPOXROCK2PRKG1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |