Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 13/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 11/20 | 0.48 |
| ▸ | ITGB7 | P26010 | 8/20 | 0.48 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850851 | 0.92 | ALDH1A1 (0.43) | ITGB1ITGA4ITGB7ALDH1A1KDM4E | |
| SCHEMBL4458134 | 0.92 | ITGB1 (0.42) | ITGB1ITGA4ITGB7ITGA5ALDH1A1 | |
| SCHEMBL3851987 | 0.88 | ITGA4 (0.56) | ITGB1ITGA4ITGB7ITGA5ALDH1A1 | |
| SCHEMBL3854086 | 0.87 | ITGB1 (0.46) | ITGB1ITGA4ITGB7ITGA5ALDH1A1 | |
| SCHEMBL3857969 | 0.87 | ITGB1 (0.46) | ITGB1ITGA4ITGB7ITGA5ALDH1A1 | |
| SCHEMBL7610114 | 0.85 | ITGB1 (0.48) | ITGB1ITGA4ITGB7ITGA5ALDH1A1 | |
| SCHEMBL3855617 | 0.85 | ITGB1 (0.51) | ITGB1ITGA4ITGB7ITGA5ALDH1A1 | |
| SCHEMBL4412675 | 0.83 | KDM4E (0.40) | ITGB1ITGA4ITGB7ALDH1A1KDM4E | |
| SCHEMBL4413756 | 0.82 | ITGB1 (0.53) | ITGB1ITGA4ITGB7ITGA5ITGA2 | |
| SCHEMBL6429310 | 0.81 | ITGB1 (0.51) | ITGB1ITGA4ITGB7ITGA5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635822-A4 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | ELAN PHARM INC (US) | 2009-06-24 | — | — | EP | disclosed |
| EP-1635822-A2 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | Elan Pharmaceuticals, Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005000246-A2 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | ELAN PHARMACEUTICALS, INC. (US) | 2005-01-06 | — | — | WO | disclosed |