Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 6/20 | 0.36 |
| ▸ | PPARD | Q03181 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.36 |
| ▸ | PTGES | O14684 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 9/20 | 0.35 |
| ▸ | CNR1 | P21554 | 7/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460417 | 0.89 | PPARG (0.39) | TSHRPPARGPPARDPPARAPTGES | |
| SCHEMBL4448976 | 0.84 | TSHR (0.42) | TSHRPPARACNR2CNR1 | |
| SCHEMBL4450305 | 0.81 | PPARG (0.38) | TSHRPPARGPPARDPPARAPTGES | |
| SCHEMBL4450027 | 0.80 | BRD4 (0.44) | PPARGPPARACNR2CNR1 | |
| SCHEMBL4450029 | 0.78 | CYSLTR2 (0.36) | TSHRPPARGPPARACNR2CNR1 | |
| SCHEMBL4453277 | 0.72 | LTB4R (0.47) | TSHRCNR2CNR1 | |
| SCHEMBL13956434 | 0.72 | LTB4R (0.47) | TSHRCNR2CNR1 | |
| SCHEMBL4445408 | 0.70 | TSHR (0.41) | TSHRPPARACNR2CNR1 | |
| SCHEMBL4445414 | 0.70 | TSHR (0.41) | TSHRPPARACNR2CNR1 | |
| SCHEMBL13956465 | 0.70 | TSHR (0.56) | TSHRPPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482484-B2 | Carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia | MERCK PATENT GMBH (DE) | 2009-01-27 | — | — | US | disclosed |