Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450130 | 1.00 | KDM4E (0.30) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL4450134 | 1.00 | KDM4E (0.30) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL449597 | 0.84 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL17164340 | 0.82 | — | — | |
| SCHEMBL17164341 | 0.82 | — | — | |
| SCHEMBL17164339 | 0.82 | — | — | |
| SCHEMBL15961195 | 0.71 | — | — | |
| SCHEMBL15961193 | 0.71 | — | — | |
| SCHEMBL209689 | 0.71 | TRPA1 (0.34) | — | |
| SCHEMBL444958 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492377-B2 | MTKI quinazoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2013-07-23 | — | — | US | claimed |
| CN-101528235-A | Vegfr3 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2009-09-09 | — | — | CN | disclosed |
| EP-2089710-A2 | A METHOD FOR PHARMACOLOGICALLY PROFILING COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008049930-A2 | A METHOD FOR PROFILING KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-05-02 | — | — | WO | disclosed |