Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 7/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.53 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1458410 | 0.91 | AGTR2 (0.53) | AGTR2AGTR1GP6 | |
| SCHEMBL4300556 | 0.91 | AGTR2 (0.53) | AGTR2AGTR1GP6 | |
| SCHEMBL4447594 | 0.90 | AGTR2 (0.54) | AGTR2AGTR1GP6 | |
| SCHEMBL4300560 | 0.89 | AGTR2 (0.54) | AGTR2AGTR1GP6 | |
| SCHEMBL4302419 | 0.87 | AGTR2 (0.53) | AGTR2AGTR1GP6 | |
| SCHEMBL1458651 | 0.84 | TLR7 (0.48) | AGTR2AGTR1GP6 | |
| SCHEMBL1459467 | 0.83 | AGTR1 (0.52) | AGTR2AGTR1GP6 | |
| SCHEMBL2279624 | 0.82 | AGTR1 (0.52) | AGTR2AGTR1GP6 | |
| SCHEMBL9149184 | 0.82 | AGTR2 (0.51) | AGTR2AGTR1GP6 | |
| SCHEMBL1458517 | 0.81 | AGTR1 (0.56) | AGTR2AGTR1GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227497-B2 | Dual-acting antihypertensive agents | THERAVANCE, INC. (US) | 2012-07-24 | — | — | US | disclosed |
| EP-2297113-A1 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009134741-A1 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2009-11-05 | — | — | WO | disclosed |