Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658199 | 0.82 | GAA (0.57) | GAAFFAR1ALDH1A1TNFPDE4A | |
| SCHEMBL1682681 | 0.82 | GAA (0.77) | GAAFFAR1ALDH1A1PDE4DTDP1 | |
| SCHEMBL3657093 | 0.82 | GAA (0.57) | GAAFFAR1ALDH1A1TNFPDE4A | |
| SCHEMBL14408318 | 0.81 | ALDH1A1 (0.47) | GAAFFAR1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL3659654 | 0.81 | GAA (0.56) | GAAFFAR1TNFPDE4APDE4B | |
| SCHEMBL3655663 | 0.81 | GAA (0.56) | GAAFFAR1TNFPDE4APDE4B | |
| SCHEMBL2495059 | 0.79 | AKR1C3 (0.58) | GAAALDH1A1CYP1A2CYP2D6HPGD | |
| SCHEMBL4459435 | 0.77 | GAA (0.48) | GAAFFAR1 | |
| SCHEMBL11225638 | 0.76 | FFAR1 (0.56) | GAAFFAR1TNFPOLBACHE | |
| SCHEMBL28628025 | 0.76 | FFAR1 (0.59) | GAAFFAR1ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482484-B2 | Carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia | MERCK PATENT GMBH (DE) | 2009-01-27 | — | — | US | disclosed |