Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 11/20 | 0.75 |
| ▸ | GABRB2 | P47870 | 11/20 | 0.75 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.72 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MDH2 | P40926 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650044 | 0.96 | GABRA1 (0.70) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| Monofluoroacetamide SCHEMBL4564454 | 0.92 | GABRA1 (0.65) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL4650038 | 0.90 | GABRA1 (0.62) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL4650642 | 0.89 | KDM4E (0.72) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL28287746 | 0.89 | GABRA1 (0.72) | GABRA1GABRB2GABRB1GABRA3ALDH1A1 | |
| SCHEMBL1024113 | 0.89 | GABRA1 (0.61) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL1022143 | 0.86 | GABRA1 (0.61) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL28289151 | 0.86 | GABRA1 (0.71) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL17338615 | 0.85 | GABRA1 (0.61) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL17338553 | 0.85 | KDM4E (0.59) | GABRA1GABRB2GABRB1GABRA3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014125506-A2 | A PROCESS FOR THE PREPARATION OF IVACAFTOR AND ITS INTERMEDIATES | LAURUS LABS PRIVATE LIMITED (IN) | 2014-08-21 | — | — | WO | claimed |
| WO-2009040377-A2 | IMAGING AGENTS | GE HEALTHCARE LIMITED (GB) | 2009-04-02 | — | — | WO | claimed |
| EP-3344249-A1 | PROCESSES FOR THE PREPARATION OF IVACAFTOR | Laurus Labs Private Limited (IN) | 2018-07-11 | — | — | EP | disclosed |
| EP-3145914-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL Business PLC (GB) | 2017-03-29 | — | — | EP | disclosed |
| WO-2017037672-A1 | PROCESSES FOR THE PREPARATION OF IVACAFTOR | LAURUS LABS PRIVATE LIMITED (IN) | 2017-03-09 | — | — | WO | disclosed |
| WO-2015189560-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL BUSINESS PLC (GB) | 2015-12-17 | — | — | WO | disclosed |
| WO-2014125506-A2 | A PROCESS FOR THE PREPARATION OF IVACAFTOR AND ITS INTERMEDIATES | LAURUS LABS PRIVATE LIMITED (IN) | 2014-08-21 | — | — | WO | disclosed |
| WO-2009040377-A2 | IMAGING AGENTS | GE HEALTHCARE LIMITED (GB) | 2009-04-02 | — | — | WO | disclosed |
| WO-2009040377-A2 | IMAGING AGENTS | GE HEALTHCARE LIMITED (GB) | 2009-04-02 | — | — | WO | disclosed |