Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.61 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.61 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4451135 | 0.89 | GABRA1 (0.75) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL4650038 | 0.88 | GABRA1 (0.62) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL4650044 | 0.86 | GABRA1 (0.70) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL5670820 | 0.86 | GABRA1 (0.60) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL6620700 | 0.84 | KDM4E (1.00) | KDM4EHPGDHSD17B10MEN1USP2 | |
| Monofluoroacetamide SCHEMBL4564454 | 0.84 | GABRA1 (0.65) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL1022143 | 0.84 | GABRA1 (0.61) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL4650158 | 0.83 | GABRA1 (0.58) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL17338615 | 0.83 | GABRA1 (0.61) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL17338553 | 0.83 | KDM4E (0.59) | KDM4EGABRA1GABRB2GABRB1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | claimed |