Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 7/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.59 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819539 | 0.89 | HDAC3 (0.60) | HDAC4HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL8609928 | 0.88 | HPGD (0.65) | HDAC4HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4895996 | 0.86 | HDAC3 (0.58) | HDAC4HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3819531 | 0.84 | HDAC3 (0.60) | HDAC4HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL16016632 | 0.82 | HDAC3 (0.61) | HDAC4HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL8079289 | 0.81 | NPC1 (0.62) | HDAC4HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL19879879 | 0.79 | HPGD (0.60) | HPGDKCNQ2KMT2AGAAPKM | |
| SCHEMBL20179113 | 0.79 | HDAC1 (0.80) | HDAC4HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL25248640 | 0.79 | HDAC3 (0.72) | HDAC4HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4420808 | 0.76 | EPHX2 (0.79) | HDAC4HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124555-A1 | USE OF HISTOGRANIN AND HISTOGRANIN-LIKE COMPOUNDS AS INHIBITORS OF P2X7 RECEPTOR FUNCTION AND AS ANTI-ARTHRITIC AGENTS | BERNATCHEZ-LEMAIRE IRMA | 2009-05-14 | — | — | US | disclosed |
| WO-2007025366-A1 | USE OF HISTOGRANIN AND HISTOGRANIN-LIKE COMPOUNDS AS INHIBITORS OF P2X7 RECEPTOR FUNCTION AND AS ANTI-ARTHRITIC AGENTS | BERNATCHEZ-LEMAIRE IRMA (CA) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124555-A1 | USE OF HISTOGRANIN AND HISTOGRANIN-LIKE COMPOUNDS AS INHIBITORS OF P2X7 RECEPTOR FUNCTION AND AS ANTI-ARTHRITIC AGENTS | P2RX5, P2RX3, P2RX2 | HDAC4 2740/4885HDAC3 3143/4885HDAC1 3559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.