Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.51 |
| ▸ | DNM2 | P50570 | 3/20 | 0.49 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL754956 | 1.00 | KMT2A (0.53) | KMT2ATLR8DNM2KCNH3TLR7 | |
| SCHEMBL3300077 | 1.00 | KMT2A (0.53) | KMT2ATLR8DNM2KCNH3TLR7 | |
| SCHEMBL3296575 | 1.00 | KMT2A (0.53) | KMT2ATLR8DNM2KCNH3TLR7 | |
| SCHEMBL1034958 | 1.00 | KMT2A (0.53) | KMT2ATLR8DNM2KCNH3TLR7 | |
| SCHEMBL3301367 | 1.00 | KMT2A (0.53) | KMT2ATLR8DNM2KCNH3TLR7 | |
| SCHEMBL468517 | 1.00 | KMT2A (0.53) | KMT2ATLR8DNM2KCNH3TLR7 | |
| SCHEMBL8752650 | 1.00 | KMT2A (0.53) | KMT2ATLR8DNM2KCNH3TLR7 | |
| SCHEMBL3301451 | 1.00 | KMT2A (0.53) | KMT2ATLR8DNM2KCNH3TLR7 | |
| SCHEMBL3297429 | 1.00 | KMT2A (0.53) | KMT2ATLR8DNM2KCNH3TLR7 | |
| SCHEMBL2851069 | 0.98 | TLR8 (0.53) | KMT2ATLR8DNM2KCNH3TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090041715-A1 | Epothilone Combinations | NOVARTIS AG (CH) | 2009-02-12 | — | — | US | claimed |
| EP-1773334-A1 | EPOTHILONE COMBINATIONS | Novartis AG (CH) | 2007-04-18 | — | — | EP | claimed |
| WO-2006010585-A1 | EPOTHILONE COMBINATIONS | NOVARTIS AG (CH) | 2006-02-02 | — | — | WO | claimed |
| US-20090041715-A1 | Epothilone Combinations | NOVARTIS AG (CH) | 2009-02-12 | — | — | US | disclosed |
| CN-1988904-A | Epothilone combinations | NOVARTIS AG (CH) | 2007-06-27 | — | — | CN | disclosed |
| EP-1773334-A1 | EPOTHILONE COMBINATIONS | Novartis AG (CH) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006010585-A1 | EPOTHILONE COMBINATIONS | NOVARTIS AG (CH) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090041715-A1 | Epothilone Combinations | EPOR, ETV6, ERAL1 | KMT2A 1637/4885TLR8 1972/4885DNM2 1916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.