Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 8/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4451937 | 1.00 | LMNA (0.44) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL4334437 | 0.90 | LMNA (0.46) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL4334434 | 0.90 | LMNA (0.46) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL4331984 | 0.90 | LMNA (0.48) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL4331981 | 0.90 | LMNA (0.48) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL4334847 | 0.89 | LMNA (0.49) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL4334844 | 0.89 | LMNA (0.49) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL4455943 | 0.88 | ALDH1A1 (0.50) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL4455942 | 0.88 | ALDH1A1 (0.50) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL13612379 | 0.88 | CHRM2 (0.38) | LMNAMAPTHTTSMN1; SMN2ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521062-B2 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2009-04-21 | — | — | US | disclosed |
| US-7521062-B2 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2009-04-21 | — | — | US | disclosed |
| US-7521062-B2 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2009-04-21 | — | — | US | disclosed |