Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | ELANE | P08246 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8647999 | 0.84 | KDM4E (0.62) | ALDH1A1KDM4EHSD17B10HPGDELANE | |
| SCHEMBL4494789 | 0.82 | KDM4E (0.69) | ALDH1A1KDM4EHSD17B10HPGDL3MBTL1 | |
| SCHEMBL4479538 | 0.77 | ALDH1A1 (0.55) | ALDH1A1KDM4EHSD17B10HPGDL3MBTL1 | |
| SCHEMBL6239360 | 0.77 | CMA1 (0.53) | KDM4EHSD17B10ELANE | |
| SCHEMBL23460839 | 0.77 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10HPGDL3MBTL1 | |
| SCHEMBL6804111 | 0.76 | CMA1 (0.53) | KDM4EHSD17B10ELANE | |
| Hydrochloric Acid SCHEMBL6805327 | 0.76 | CMA1 (0.53) | KDM4EHSD17B10ELANE | |
| SCHEMBL2801401 | 0.75 | APEX1 (0.44) | ALDH1A1KDM4EHSD17B10HPGDAPEX1 | |
| SCHEMBL4456432 | 0.75 | APEX1 (0.42) | ALDH1A1KDM4EL3MBTL1APEX1KMT2A | |
| SCHEMBL5503526 | 0.75 | KDM4E (0.59) | ALDH1A1KDM4EHSD17B10HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020183249-A1 | Method of identifying inhibitors of CDC25 | TAYLOR NEIL R (AU) | 2002-12-05 | — | — | US | claimed |
| EP-2123665-A2 | Inhibitors of interleukin-1Beta converting enzyme | Vertex Pharmaceuticals Incorporated (US) | 2009-11-25 | — | — | EP | disclosed |
| EP-1394175-A1 | Inhibitors of interleukin-1beta converting enzyme | Vertex Pharmaceuticals Incorporated (US) | 2004-03-03 | — | — | EP | disclosed |
| US-20020183249-A1 | Method of identifying inhibitors of CDC25 | TAYLOR NEIL R (AU) | 2002-12-05 | — | — | US | disclosed |
| US-6420522-B1 | ENZYME INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2002-07-16 | — | — | US | disclosed |
| US-5656627-A | USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE AND NEURODEGENERATIVE DISEASES | VERTEX PHARMACEUTICALS, INC. (US) | 1997-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183249-A1 | Method of identifying inhibitors of CDC25 | CDC25C, CDC25A, CDC25B | ALDH1A1 4243/4885KDM4E 4246/4885HSD17B10 2458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.