Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494789 | 0.87 | KDM4E (0.69) | KDM4EALDH1A1HSD17B10HPGDL3MBTL1 | |
| SCHEMBL8269666 | 0.79 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL8269516 | 0.77 | ALDH1A1 (0.66) | KDM4EALDH1A1HSD17B10HPGDL3MBTL1 | |
| SCHEMBL4491252 | 0.75 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10HPGDL3MBTL1 | |
| SCHEMBL4479538 | 0.75 | ALDH1A1 (0.55) | KDM4EALDH1A1HSD17B10HPGDL3MBTL1 | |
| SCHEMBL4452759 | 0.75 | ALDH1A1 (0.59) | KDM4EALDH1A1HSD17B10HPGDL3MBTL1 | |
| SCHEMBL8269506 | 0.75 | BACE1 (0.60) | KDM4EALDH1A1HSD17B10HPGDL3MBTL1 | |
| SCHEMBL4483861 | 0.73 | BACE1 (0.61) | KDM4EALDH1A1HSD17B10HPGDL3MBTL1 | |
| SCHEMBL22769616 | 0.73 | BACE1 (0.54) | KDM4EALDH1A1HSD17B10HPGDL3MBTL1 | |
| SCHEMBL11272994 | 0.71 | L3MBTL1 (0.53) | KDM4EALDH1A1HSD17B10HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848692-A1 | AZOLYLACYLGUANIDINES AS ß-SECRETASE INHIBITORS | Wyeth (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006088711-A1 | AZOLYLACYLGUANIDINES AS β-SECRETASE INHIBITORS | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |