SCHEMBL4453024

SCHEMBL4453024

Nc1cccc2c(S(=O)(=O)NCc3cccc(F)c3)cccc12

nearest known ligand 0.78

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NSD2 O96028 16/20 0.78
CYP19A1 P11511 1/20 0.52
PLK1 P53350 1/20 0.49
NPY5R Q15761 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4441215 0.99 NSD2 (0.79) NSD2CYP19A1PLK1NPY5R
SCHEMBL4448428 0.91 NSD2 (0.80) NSD2CYP19A1
Hydrochloric Acid SCHEMBL4444943 0.90 NSD2 (0.81) NSD2CYP19A1
SCHEMBL4445013 0.88 NSD2 (1.00) NSD2
SCHEMBL4443035 0.86 NSD2 (0.77) NSD2CYP19A1NPY5R
Hydrochloric Acid SCHEMBL4445433 0.86 NSD2 (1.00) NSD2
SCHEMBL4445049 0.86 NSD2 (0.76) NSD2CYP19A1NPY5R
Hydrochloric Acid SCHEMBL4448179 0.85 NSD2 (0.78) NSD2CYP19A1NPY5R
SCHEMBL4441197 0.85 NSD2 (1.00) NSD2NPY5R
Hydrochloric Acid SCHEMBL4443383 0.85 NSD2 (0.77) NSD2CYP19A1NPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7547716-B2 Sulfonamide derivatives INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2009-06-16 US claimed