Di(Hydroxyethyl)Ether

Di(Hydroxyethyl)Ether

SCHEMBL4453213

CC(=O)O.CCCCOCCCC.OCCOCCO

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.77
MEN1 O00255 3/20 0.61
KMT2A Q03164 3/20 0.61
THRB P10828 1/20 0.61
HTT P42858 1/20 0.61
MAPT P10636 1/20 0.61
ALDH1A1 P00352 3/20 0.48
CES2 O00748 1/20 0.47
MAPK1 P28482 2/20 0.46
CYP3A4 P08684 2/20 0.43
ACHE P22303 1/20 0.42
RARB P10826 1/20 0.41
USP2 O75604 1/20 0.41
LMNA P02545 1/20 0.41
CASP1 P29466 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
SLCO1B3 Q9NPD5 1/20 0.41
SLCO1B1 Q9Y6L6 1/20 0.41
ATM Q13315 1/20 0.40
HCAR2 Q8TDS4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butoxyethanol SCHEMBL587577 1.00 TSHR (0.77) TSHRMEN1KMT2ATHRBHTT
Acetic Acid SCHEMBL2516099 0.98 TSHR (0.74) TSHRMEN1KMT2ATHRBHTT
Acetic Acid SCHEMBL8327649 0.98 TSHR (0.74) TSHRMEN1KMT2ATHRBHTT
Triethylene Glycol SCHEMBL275016 0.98 TSHR (0.74) TSHRMEN1KMT2ATHRBHTT
Acetic Acid SCHEMBL28870592 0.98 TSHR (0.74) TSHRMEN1KMT2ATHRBHTT
Butoxyethanol SCHEMBL26126895 0.94 TSHR (0.68) TSHRMEN1KMT2ATHRBHTT
Acetic Acid SCHEMBL28282561 0.93 MEN1 (0.72) TSHRMEN1KMT2ATHRBHTT
Butoxyethanol SCHEMBL11512114 0.93 TSHR (0.81) TSHRMEN1KMT2ATHRBHTT
Acetic Acid SCHEMBL99361 0.93 TSHR (0.65) TSHRMEN1KMT2ATHRBHTT
Triethylene Glycol SCHEMBL19064944 0.91 MEN1 (0.76) TSHRMEN1KMT2ATHRBHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150045260-A1 Thermal Insulating Fluids BANK OF AMERICA, N.A. (AS SUCCESSOR ADMINISTRATIVE AGENT TO JPMORGAN CHASE BANK, N.A.) 2015-02-12 US claimed
US-8895476-B2 Thermal insulating fluids TETRA TECHNOLOGIES, INC. (US) 2014-11-25 US claimed
US-20120231977-A1 Thermal Insulating Fluids TETRA TECHNOLOGIES, INC. (US) 2012-09-13 US claimed
WO-2012121995-A2 THERMAL INSULATING FLUIDS TETRA TECHNOLOGIES, INC. (US) 2012-09-13 WO claimed
WO-2008081045-A1 COMPOSITION AND METHOD FOR STRIPPING ORGANIC COATINGS BASF SE (DE) 2008-07-10 WO claimed
WO-2007104746-A1 CLEANING COMPOSITION FOR REMOVING POST-DRY-ETCH RESIDUES BASF AKTIENGESELLSCHAFT (DE) 2007-09-20 WO claimed
US-20230157174-A1 THERMOELECTRIC CONVERSION MODULE NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2023-05-18 US disclosed
EP-4099411-A1 THERMOELECTRIC CONVERSION MODULE NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2022-12-07 EP disclosed
US-9523028-B2 Thermal insulating fluids TETRA TECHNOLOGIES, INC. (US) 2016-12-20 US disclosed
US-20150045260-A1 Thermal Insulating Fluids BANK OF AMERICA, N.A. (AS SUCCESSOR ADMINISTRATIVE AGENT TO JPMORGAN CHASE BANK, N.A.) 2015-02-12 US disclosed
US-8895476-B2 Thermal insulating fluids TETRA TECHNOLOGIES, INC. (US) 2014-11-25 US disclosed
US-20120231977-A1 Thermal Insulating Fluids TETRA TECHNOLOGIES, INC. (US) 2012-09-13 US disclosed
WO-2012121995-A2 THERMAL INSULATING FLUIDS TETRA TECHNOLOGIES, INC. (US) 2012-09-13 WO disclosed
WO-2007104746-A1 CLEANING COMPOSITION FOR REMOVING POST-DRY-ETCH RESIDUES BASF AKTIENGESELLSCHAFT (DE) 2007-09-20 WO disclosed
EP-1829945-A1 FILM, SILICA FILM AND METHOD OF FORMING THE SAME, COMPOSITION FOR FORMING SILICA FILM, AND ELECTRONIC PART Hitachi Chemical Co., Ltd. (JP) 2007-09-05 EP disclosed
EP-1474456-B1 ALTERNATING COPOLYMERS OF ISOBUTYLENE TYPE MONOMERS PPG IND OHIO INC (US) 2007-03-14 EP disclosed
US-7132476-B2 Thermosetting compositions containing alternating copolymers of isobutylene type monomers PPG INDUSTRIES OHIO, INC. (US) 2006-11-07 US disclosed
CN-1522388-A Photosensitive resin composition, method for producing pattern and electronic parts 日立化成工业株式会社 2004-08-18 CN disclosed
US-5985791-A COMPRISING A SUPPORT, AND THERMOSENSITIVE RECORDING LAYER CONTAINING AN ELECTRON-DONATING COLORING COMPOUND, AN ELECTRON-ACCEPTING COMPOUND, A BINDER RESIN, A LIQUID RESIN WHICH IS IN A LIQUID STATE AT ROOM TEMPERATURE, AND A RICOH COMPANY, LTD (JP) 1999-11-16 US disclosed
US-4347062-A Complexes of high iron content soluble in organic media and usable as combustion additives in liquid fuels INSTITUT FRANCAIS DU PETROLE (FR) 1982-08-31 US disclosed