Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309078 | 0.87 | DPP4 (0.41) | DPP4DPP8EGLN3LMNAADORA2B | |
| SCHEMBL12894983 | 0.83 | DHODH (0.43) | DPP4DPP8EGLN3DHODHAGER | |
| SCHEMBL3042449 | 0.83 | LMNA (0.43) | DPP4DPP8LMNAADORA2BMEN1 | |
| SCHEMBL28442608 | 0.81 | CYP11B1 (0.54) | DPP4ADORA2BMEN1TP53PABPC1 | |
| SCHEMBL7425056 | 0.78 | DHODH (0.49) | DPP4DPP8EGLN3DHODHAGER | |
| SCHEMBL14291769 | 0.78 | DPP4 (0.49) | DPP4DPP8EGLN3LMNAADORA2B | |
| SCHEMBL308832 | 0.76 | DPP4 (0.58) | DPP4DPP8EGLN3LMNAADORA2B | |
| SCHEMBL3029115 | 0.76 | PRPS1 (0.51) | DPP4DPP8EGLN3LMNAADORA2B | |
| Hydrochloric Acid SCHEMBL7426484 | 0.76 | DHODH (0.48) | DPP4DPP8EGLN3DHODHAGER | |
| SCHEMBL307334 | 0.76 | DPP4 (0.45) | DPP4DPP8EGLN3LMNAADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | claimed |