SCHEMBL4453409

SCHEMBL4453409

O=CCc1ccc(OCc2ccc(Cl)c(Cl)c2)cc1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 3/20 0.54
S1PR1 P21453 1/20 0.52
HTR2A P28223 1/20 0.52
KCNH2 Q12809 1/20 0.52
SIGMAR1 Q99720 1/20 0.52
S1PR5 Q9H228 1/20 0.52
MAOB P27338 5/20 0.51
MAOA P21397 2/20 0.51
FFAR1 O14842 3/20 0.49
IDO1 P14902 2/20 0.49
MRGPRX4 Q96LA9 1/20 0.48
CYP2D6 P10635 2/20 0.47
NPC1 O15118 1/20 0.46
ALDH1A1 P00352 1/20 0.46
CYP2C19 P33261 1/20 0.46
PTGDR2 Q9Y5Y4 1/20 0.45
RAB9A P51151 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3038004 0.85 RAB9A (0.63) PTPN1S1PR1HTR2AKCNH2SIGMAR1
SCHEMBL11118881 0.82 MRGPRX4 (0.59) PTPN1S1PR1HTR2AKCNH2SIGMAR1
SCHEMBL5512534 0.81 IDO1 (0.53) PTPN1S1PR1HTR2AKCNH2SIGMAR1
SCHEMBL28115794 0.81 MAOB (0.69) S1PR1S1PR5MAOBMAOA
SCHEMBL539627 0.80 S1PR1 (0.53) PTPN1S1PR1HTR2AKCNH2SIGMAR1
SCHEMBL1780435 0.80 IDO1 (0.54) SIGMAR1IDO1NPC1ALDH1A1RAB9A
SCHEMBL1508320 0.80 CYP2D6 (0.53) PTPN1S1PR1HTR2AKCNH2SIGMAR1
SCHEMBL12584867 0.79 MAOB (0.54) PTPN1S1PR1HTR2AKCNH2SIGMAR1
SCHEMBL1508212 0.79 APP (0.56) PTPN1S1PR1HTR2AKCNH2SIGMAR1
SCHEMBL508773 0.79 S1PR1 (0.55) PTPN1S1PR1HTR2AKCNH2SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2046308-A2 RETINOIDS AND SMALL MOLECULES AS NRF2 ANTAGONISTS FOR USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL CELL PROLIFERATION The University Court of the University of Dundee (GB) 2009-04-15 EP disclosed
WO-2008012534-A2 RETINOIDS AND SMALL MOLECULES AS NRF2 ANTAGONISTS FOR USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL CELL PROLIFERATION THE UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) 2008-01-31 WO disclosed