SCHEMBL445354

SCHEMBL445354

CC(C)(C)[Si](C)(C)OCCC(O)(CO)c1ccc(F)c(Br)c1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 4/20 0.31
APLNR P35414 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL445353 1.00 IDO1 (0.31) IDO1APLNR
SCHEMBL381235 0.89 APLNR (0.32) IDO1APLNR
SCHEMBL380224 0.83 APLNR (0.33) IDO1APLNR
SCHEMBL380225 0.83 APLNR (0.33) IDO1APLNR
SCHEMBL4156016 0.76 CYP2C19 (0.36)
SCHEMBL7498467 0.72 DUT (0.33)
SCHEMBL27478289 0.72 DUT (0.33)
SCHEMBL30221972 0.71 DUT (0.34) IDO1APLNR
SCHEMBL20521475 0.71 DUT (0.34) IDO1APLNR
SCHEMBL25356197 0.70 DUT (0.36) IDO1APLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2409977-A1 AMIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2012-01-25 EP disclosed