Sugi Predict

Sugi Predict / Compounds / SCHEMBL4453824

SCHEMBL4453824

SCHEMBL4453824

CC(=O)Oc1cccc2ccc(Cl)nc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.50
▸ ALDH1A1 P00352 4/20 0.50
▸ MEN1 O00255 3/20 0.50
▸ HPGD P15428 3/20 0.50
▸ NPC1 O15118 2/20 0.50
▸ RAB9A P51151 2/20 0.50
▸ LMNA P02545 2/20 0.50
▸ SMN1; SMN2 Q16637 2/20 0.50
▸ TP53 P04637 1/20 0.50
▸ MCHR1 Q99705 1/20 0.46
▸ TDP1 Q9NUW8 4/20 0.46
▸ PDE10A Q9Y233 3/20 0.46
▸ CYP3A4 P08684 3/20 0.46
▸ KDM4E B2RXH2 3/20 0.46
▸ ALOX12 P18054 1/20 0.46
▸ MAPT P10636 3/20 0.43
▸ POLB P06746 2/20 0.43
▸ CYP1A2 P05177 2/20 0.43
▸ CYP2C19 P33261 2/20 0.43
▸ CYP2C9 P11712 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7171403 0.85 HSP90AA1 (0.44) KMT2AALDH1A1MEN1HPGDNPC1
SCHEMBL29014906 0.84 MCHR1 (0.44) KMT2AALDH1A1MEN1HPGDNPC1
SCHEMBL5210685 0.84 MCHR1 (0.63) KMT2AALDH1A1MEN1HPGDNPC1
SCHEMBL28555834 0.82 CYP1A2 (0.60) KMT2AALDH1A1MEN1HPGDNPC1
SCHEMBL15532332 0.82 KMT2A (0.51) KMT2AALDH1A1MEN1HPGDNPC1
SCHEMBL11924545 0.81 KMT2A (0.48) KMT2AALDH1A1MEN1HPGDNPC1
SCHEMBL19603065 0.81 KMT2A (0.50) KMT2AALDH1A1MEN1HPGDNPC1
SCHEMBL28662218 0.81 KMT2A (0.50) KMT2AALDH1A1MEN1HPGDNPC1
SCHEMBL4453463 0.81 KMT2A (0.50) KMT2AALDH1A1MEN1HPGDNPC1
SCHEMBL1162324 0.79 KDM4E (0.57) KMT2AALDH1A1MEN1HPGDNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117658998-A Herbicidal compositions comprising R-pyridyloxycarboxylic acid derivatives and use thereof 青岛清原化合物有限公司 2024-03-08 — — CN disclosed
CN-117652508-A Herbicidal compositions comprising carboxylic acid derivative substituted oxyiminoaryl compounds and uses thereof 青岛清原化合物有限公司 2024-03-08 — — CN disclosed
CN-114431236-B Ternary herbicidal compositions comprising carboxylic acid derivative substituted oxyiminoaryl compounds and uses thereof 青岛清原化合物有限公司 2024-02-02 — — CN disclosed
CN-114431244-B Ternary herbicidal compositions comprising HPPD inhibitor herbicides and uses thereof 青岛清原化合物有限公司 2024-02-02 — — CN disclosed
CN-116965414-A Weeding composition containing pyrimidine formyl oxime derivative and application thereof 青岛清原作物科学有限公司 2023-10-31 — — CN disclosed
CN-116941626-A Weeding composition containing condensed ring substituted aromatic compound and application thereof 青岛清原作物科学有限公司 2023-10-27 — — CN disclosed
CN-116849220-A Binary weeding composition and application thereof 青岛清原化合物有限公司 2023-10-10 — — CN disclosed
CN-114304165-B Binary weeding composition and application thereof 青岛清原化合物有限公司 2023-07-07 — — CN disclosed
CN-116250539-A Ternary weeding composition containing fenpyrazamine and application thereof 青岛清原化合物有限公司 2023-06-13 — — CN disclosed
US-9302993-B2 8-hydroxy quinoline derivatives PRANA BIOTECHNOLOGY LIMITED (AU) 2016-04-05 — — US disclosed
US-9169211-B2 8-hydroxy quinoline derivatives PRANA BIOTECHNOLOGY LIMITED (AU) 2015-10-27 — — US disclosed
US-20150094334-A1 8-HYDROXY QUINOLINE DERIVATIVES PRANA BIOTECHNOLOGY LIMITED (AU) 2015-04-02 — — US disclosed
US-8975278-B2 8-hydroxy quinoline derivatives PRANA BIOTECHNOLOGY LIMITED (AU) 2015-03-10 — — US disclosed
US-20150025108-A1 8-HYDROXY QUINOLINE DERIVATIVES PRANA BIOTECHNOLOGY LIMITED (AU) 2015-01-22 — — US disclosed
US-7619091-B2 Treating nervous system disorders such as mild cognitive impairment, Alzheimer's disease or dementia associated with Down syndrome; e.g. use of 5,7-dichloro-8-hydroxy-2-(2-pyridyl)-quinoline (PBT 1052) PRANA BIOTECHNOLOGY LIMITED (AU) 2009-11-17 — — US disclosed
US-20080161353-A1 8-Hydroxy quinoline derivatives PRANA BIOTECHNOLOGY LIMITED (AU) 2008-07-03 — — US disclosed
EP-1539700-A4 8-HYDROXY QUINOLINE DERIVATIVES PRANA BIOTECHNOLOGY LTD (AU) 2006-06-28 — — EP disclosed
US-20060089380-A1 8-Hydroxy quinoline derivatives PRANA BIOTECHNOLOGY LTD. (AU) 2006-04-27 — — US disclosed
EP-1539700-A1 8-HYDROXY QUINOLINE DERIVATIVES Prana Biotechnology Ltd (AU) 2005-06-15 — — EP disclosed
WO-2004007461-A1 8-HYDROXY QUINOLINE DERIVATIVES PRANA BIOTECHNOLOGY LIMITED (AU) 2004-01-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161353-A1 8-Hydroxy quinoline derivatives PARK7, COQ8A, NLN KMT2A 1762/4885ALDH1A1 725/4885MEN1 1871/4885
US-20150025108-A1 8-HYDROXY QUINOLINE DERIVATIVES PARK7, COQ8A, NLN KMT2A 1762/4885ALDH1A1 725/4885MEN1 1871/4885
US-20060089380-A1 8-Hydroxy quinoline derivatives PARK7, HTT, SNCA KMT2A 746/4885ALDH1A1 513/4885MEN1 3123/4885
US-20150094334-A1 8-HYDROXY QUINOLINE DERIVATIVES PARK7, COQ8A, NLN KMT2A 1762/4885ALDH1A1 725/4885MEN1 1871/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.