Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4449570 | 0.85 | POLB (0.43) | POLBKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL4532064 | 0.82 | POLB (0.44) | POLBKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL4454901 | 0.80 | CYP2D6 (0.42) | ALDH1A1KDM4EMAPK1 | |
| SCHEMBL4237209 | 0.77 | CYP2D6 (0.41) | ALDH1A1SIGMAR1MAPK1 | |
| SCHEMBL4522977 | 0.75 | CYP2D6 (0.47) | ALDH1A1MAPK1 | |
| SCHEMBL4519652 | 0.73 | CYP2D6 (0.41) | KMT2AALDH1A1MEN1MAPK1 | |
| SCHEMBL4518886 | 0.70 | POLB (0.43) | POLBKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL4452402 | 0.70 | CYP2D6 (0.33) | KMT2AALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL4165858 | 0.69 | POLB (0.58) | POLBKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL6079416 | 0.67 | CYP2D6 (0.45) | KMT2AALDH1A1LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2020411-A1 | SPIRO TETRACYCLIC COMPOUND | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2009-02-04 | — | — | EP | disclosed |