Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 13/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.37 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4237209 | 0.87 | CYP2D6 (0.41) | CYP2D6CHRM2CHRM3ALDH1A1MAPK1 | |
| SCHEMBL4522977 | 0.86 | CYP2D6 (0.47) | CYP2D6CHRM2CHRM3ALDH1A1MAPK1 | |
| SCHEMBL4519652 | 0.84 | CYP2D6 (0.41) | CYP2D6CHRM2CHRM3ALDH1A1MAPK1 | |
| SCHEMBL4454104 | 0.80 | POLB (0.44) | ALDH1A1MAPK1KDM4E | |
| SCHEMBL5322750 | 0.79 | CYP2D6 (0.38) | CYP2D6CHRM2CHRM3ALDH1A1CYP3A4 | |
| SCHEMBL4452402 | 0.79 | CYP2D6 (0.33) | CYP2D6CHRM2CHRM3ALDH1A1MAPK1 | |
| SCHEMBL6079416 | 0.78 | CYP2D6 (0.45) | CYP2D6CHRM2CHRM3ALDH1A1MAPK1 | |
| SCHEMBL4532180 | 0.77 | SIGMAR1 (0.42) | CYP2D6CHRM2CHRM3ALDH1A1CYP3A4 | |
| SCHEMBL4519880 | 0.77 | CYP2D6 (0.42) | CYP2D6CHRM2CHRM3ALDH1A1MAPK1 | |
| SCHEMBL4449570 | 0.76 | POLB (0.43) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2020411-A1 | SPIRO TETRACYCLIC COMPOUND | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2009-02-04 | — | — | EP | disclosed |