Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.40 |
| ▸ | BCL9 | O00512 | 3/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL478291 | 0.92 | PSEN1 (0.46) | ROCK2ROCK1CYP3A4CYP2D6NFKB1 | |
| SCHEMBL12012784 | 0.88 | BCL9 (0.42) | ROCK2ROCK1CYP3A4CYP2D6NFKB1 | |
| SCHEMBL478119 | 0.87 | BCL9 (0.42) | ROCK2ROCK1CYP3A4CYP2D6NFKB1 | |
| SCHEMBL4454311 | 0.86 | ROCK2 (0.45) | ROCK2ROCK1CYP3A4CYP2D6NFKB1 | |
| SCHEMBL4454318 | 0.85 | ROCK2 (0.45) | ROCK2ROCK1CYP3A4CYP2D6NFKB1 | |
| SCHEMBL12013100 | 0.79 | ROCK2 (0.42) | ROCK2ROCK1CYP3A4CYP2D6NFKB1 | |
| SCHEMBL478086 | 0.77 | PSEN1 (0.52) | BCL9CTNNB1SMN1; SMN2 | |
| SCHEMBL2913923 | 0.76 | ROCK2 (0.42) | ROCK2ROCK1CYP3A4CYP2D6NFKB1 | |
| SCHEMBL478039 | 0.74 | PSEN1 (0.56) | BCL9CTNNB1 | |
| SCHEMBL478136 | 0.74 | BCL9 (0.53) | BCL9CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105275-A1 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105275-A1 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE | BACE1, BACE2, PSEN1 | ROCK2 1145/4885ROCK1 668/4885CYP3A4 1969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.