Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.41 |
| ▸ | PRKCG | P05129 | 3/20 | 0.41 |
| ▸ | PRKCB | P05771 | 3/20 | 0.41 |
| ▸ | PRKCA | P17252 | 3/20 | 0.41 |
| ▸ | PRKCH | P24723 | 3/20 | 0.41 |
| ▸ | PRKCI | P41743 | 3/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454315 | 0.85 | ROCK2 (0.44) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL4454311 | 0.85 | ROCK2 (0.45) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL478291 | 0.83 | PSEN1 (0.46) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL12012784 | 0.81 | BCL9 (0.42) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL478119 | 0.81 | BCL9 (0.42) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL12013100 | 0.72 | ROCK2 (0.42) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL2913923 | 0.72 | ROCK2 (0.42) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL16712986 | 0.68 | ROCK2 (0.61) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL7315524 | 0.67 | CYP3A4 (0.62) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL4726515 | 0.67 | ROCK2 (0.68) | ROCK2ROCK1CYP3A4PRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105275-A1 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105275-A1 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE | BACE1, BACE2, PSEN1 | ROCK2 1145/4885ROCK1 668/4885CYP3A4 1969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.