Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387115 | 0.84 | GPR119 (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1GPR119 | |
| SCHEMBL4519368 | 0.83 | GPR119 (0.72) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL390747 | 0.80 | GPR119 (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1GPR119 | |
| SCHEMBL389717 | 0.72 | GPR119 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1GPR119 | |
| SCHEMBL10217753 | 0.71 | MET (0.51) | NPC1RAB9ASMN1; SMN2TP53HTT | |
| SCHEMBL17888366 | 0.71 | KDM4E (0.61) | TP53KDM4ETACR3HTR2BMEN1 | |
| SCHEMBL8889364 | 0.71 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL389587 | 0.70 | GPR119 (0.79) | NPC1RAB9ASMN1; SMN2ALDH1A1GPR119 | |
| SCHEMBL17122217 | 0.69 | GPR119 (0.84) | NPC1RAB9AGPR119KDM4EKMT2A | |
| SCHEMBL1069801 | 0.69 | GPR119 (0.74) | NPC1RAB9ASMN1; SMN2ALDH1A1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1808168-B1 | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level | ARENA PHARM INC (US) | 2009-06-03 | — | — | EP | disclosed |