Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.68 |
| ▸ | MEN1 | O00255 | 7/20 | 0.68 |
| ▸ | NPC1 | O15118 | 6/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | MTOR | P42345 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.66 |
| ▸ | IDO1 | P14902 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | GBA1 | P04062 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687148 | 0.91 | GAA (0.68) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL29493316 | 0.91 | GAA (0.68) | RAB9AKMT2AMEN1NPC1MAPT | |
| Hydrochloric Acid SCHEMBL29536454 | 0.90 | GAA (0.66) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL30851500 | 0.88 | RAB9A (0.79) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL27193042 | 0.88 | RAB9A (0.79) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL4105400 | 0.87 | RAB9A (0.74) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL4113845 | 0.87 | RAB9A (0.68) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL4555389 | 0.86 | KMT2A (0.72) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL24272323 | 0.85 | MTOR (0.69) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL4555366 | 0.83 | CASP3 (0.70) | RAB9AKMT2AMEN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404669-B2 | Kinase modulating compounds and uses thereof for treatment of cancer | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-03-26 | — | — | US | disclosed |
| WO-2012139001-A2 | KINASE PROTEIN BINDING INHIBITORS | ROSWELL PARK CANCER INSTITUTE (US) | 2012-10-11 | — | — | WO | disclosed |
| EP-2136829-A1 | KINASE PROTEIN BINDING INHIBITORS | University Of Florida Research Foundation (US) | 2009-12-30 | — | — | EP | disclosed |
| US-20090239850-A1 | Kinase protein binding inhibitors | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2009-09-24 | — | — | US | disclosed |
| WO-2008115443-A1 | KINASE PROTEIN BINDING INHIBITORS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2008-09-25 | — | — | WO | disclosed |