Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | HTR2B | P41595 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.36 |
| ▸ | PNMT | P11086 | 4/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1589928 | 0.79 | HTR2C (0.48) | HTR2CHTR2BHTR2APNMTADRA2A | |
| SCHEMBL537759 | 0.78 | HTR2C (0.50) | HTR2CHTR2BPNMTADRA2AOPRD1 | |
| Hydrochloric Acid SCHEMBL1591008 | 0.78 | HTR2C (0.47) | HTR2CHTR2BHTR2APNMTOPRD1 | |
| Hydrochloric Acid SCHEMBL3708253 | 0.77 | HTR2C (0.49) | HTR2CHTR2BPNMTADRA2AOPRD1 | |
| SCHEMBL4444741 | 0.71 | HTR2C (0.38) | HTR2CHTR2BSLC6A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL10502304 | 0.70 | HTR2C (0.49) | HTR2CHTR2BHTR2APNMTOPRD1 | |
| SCHEMBL20271017 | 0.69 | HTR2C (0.33) | HTR2CHTR2BPNMT | |
| SCHEMBL11261590 | 0.67 | HTR2C (0.49) | HTR2CHTR2BHTR2APNMTOPRD1 | |
| SCHEMBL4220742 | 0.67 | HTR2C (0.49) | HTR2CHTR2BHTR2APNMTOPRD1 | |
| SCHEMBL538019 | 0.66 | TRPM8 (0.51) | HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009037542-A2 | SPIROCYCLIC COMPOUNDS AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009037542-A2 | SPIROCYCLIC COMPOUNDS AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-03-26 | — | — | WO | disclosed |