Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.50 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.50 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454927 | 1.00 | ALDH1A1 (0.62) | ALDH1A1KDM4EALOX15MAPTPIM1 | |
| SCHEMBL16704292 | 0.91 | ALDH1A1 (0.58) | ALDH1A1KDM4EALOX15MAPTPIM1 | |
| SCHEMBL3031855 | 0.91 | ALDH1A1 (0.58) | ALDH1A1KDM4EALOX15MAPTPIM1 | |
| SCHEMBL5452087 | 0.85 | ALDH1A1 (0.62) | ALDH1A1KDM4EALOX15MAPTGSK3A | |
| SCHEMBL14627221 | 0.85 | ALDH1A1 (0.62) | ALDH1A1KDM4EALOX15MAPTGSK3A | |
| SCHEMBL11558191 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4EALOX15MAPTGSK3A | |
| SCHEMBL11558188 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4EALOX15MAPTGSK3A | |
| SCHEMBL4449592 | 0.84 | CYP3A4 (0.54) | ALDH1A1KDM4EALOX15MAPTPIM1 | |
| SCHEMBL4449591 | 0.84 | CYP3A4 (0.54) | ALDH1A1KDM4EALOX15MAPTPIM1 | |
| SCHEMBL16168568 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4EALOX15MAPTGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050452-A1 | indenoisoquinolines as topoisomerase inhibitors I useful as antineoplastic agents | Purdue Research Foundation (US) | 2009-04-22 | — | — | EP | disclosed |
| US-6509344-B1 | A method for treating a patient having cancer, said method comprising the step of administering to the patient an effective amount of a compound according to claim 1, whereupon said patient is treated for cancer, and wherein the cancer is | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2003-01-21 | — | — | US | disclosed |
| EP-1123099-A4 | NOVEL INDENOISOQUINOLINES AS ANTINEOPLASTIC AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1123099-A1 | NOVEL INDENOISOQUINOLINES AS ANTINEOPLASTIC AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000021537-A1 | NOVEL INDENOISOQUINOLINES AS ANTINEOPLASTIC AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2000-04-20 | — | — | WO | disclosed |
| EP-0190105-A2 | Herbicidal agent | CIBA-GEIGY AG (CH) | 1986-08-06 | — | — | EP | disclosed |