SCHEMBL4455430

SCHEMBL4455430

c1ccc(CCO[Si](OCCc2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA9 Q16790 1/20 0.42
IDO1 P14902 1/20 0.42
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
CASP1 P29466 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MAOB P27338 2/20 0.40
MAOA P21397 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
LTA4H P09960 1/20 0.40
TDP1 Q9NUW8 3/20 0.39
CYP2A6 P11509 1/20 0.39
HTR2A P28223 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL38650984 0.83 CA1 (0.42) CA1CA2CA9IDO1NPC1
SCHEMBL11526340 0.83 CA1 (0.42) CA1CA2CA9IDO1NPC1
SCHEMBL766905 0.80 SMN1; SMN2 (0.44) CA1CA2CA9IDO1NPC1
SCHEMBL3036323 0.79 CA1 (0.47) CA1CA2CA9IDO1NPC1
SCHEMBL18297936 0.77 TSHR (0.50) CA1CA2CA9IDO1RAB9A
SCHEMBL9911294 0.76 SMN1; SMN2 (0.44) CA1CA2CA9IDO1NPC1
SCHEMBL4237137 0.76 TDP1 (0.46) CA1CA2CA9IDO1NPC1
SCHEMBL106121 0.76 LMNA (0.39) ALDH1A1HPGDSMN1; SMN2LTA4H
SCHEMBL16463274 0.76 HDAC3 (0.38) IDO1
SCHEMBL2230509 0.75 SMN1; SMN2 (0.38) CA1CA2CA9IDO1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2066601-A1 HYDROSILYLATION Agency for Science, Technology And Research (SG) 2009-06-10 EP disclosed
WO-2008039154-A1 HYDROSILYLATION AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2008-04-03 WO disclosed