SCHEMBL4237137

SCHEMBL4237137

O[Si](O)(O)OCCc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 4/20 0.46
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA9 Q16790 1/20 0.44
IDO1 P14902 1/20 0.43
HCAR2 Q8TDS4 1/20 0.43
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
ALDH1A1 P00352 2/20 0.42
HPGD P15428 2/20 0.42
HSD17B10 Q99714 2/20 0.42
ALOX15 P16050 1/20 0.42
ALOX12 P18054 1/20 0.42
CASP1 P29466 1/20 0.42
FFAR1 O14842 1/20 0.42
ESR1 P03372 1/20 0.42
ESR2 Q92731 1/20 0.42
KEAP1 Q14145 1/20 0.41
LMNA P02545 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25190743 0.87 IDO1 (0.55) TDP1IDO1NPC1RAB9AFFAR1
SCHEMBL3036323 0.81 CA1 (0.47) TDP1CA1CA2CA9IDO1
SCHEMBL766905 0.77 SMN1; SMN2 (0.44) TDP1CA1CA2CA9IDO1
SCHEMBL9911294 0.77 SMN1; SMN2 (0.44) TDP1CA1CA2CA9IDO1
SCHEMBL251775 0.77 IDO1 (0.40) TDP1CA1CA2CA9IDO1
SCHEMBL997761 0.76 TSHR (0.52) TDP1CA1CA2CA9IDO1
SCHEMBL4455430 0.76 CA1 (0.42) TDP1CA1CA2CA9IDO1
SCHEMBL11526340 0.76 CA1 (0.42) TDP1CA1CA2CA9IDO1
SCHEMBL38650984 0.76 CA1 (0.42) TDP1CA1CA2CA9IDO1
SCHEMBL10629421 0.74 CA1 (0.41) TDP1CA1CA2CA9IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0185526-B1 SOLVENT SOLUBLE FLUORINE-CONTAINING POLYMER, COATING COMPOSITION CONTAINING THE SAME AND COATING PROCESS THEREOF MITSUI SEKIYU KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-03-13 EP claimed
US-4737444-A UNDERCOATING IS POLYMER CONTAINING METAL ALCOHOLATE RICOH COMPANY, LTD. (JP) 1988-04-12 US claimed
CN-107049842-A The Solic cosmetic composition of compacted powder form 莱雅公司 2017-08-18 CN disclosed
US-9587206-B2 Combination of an amino alcohol, a fragrance and a silicic acid ester, and the use of same as a pro-fragrance HENKEL AG & CO. KGAA (DE) 2017-03-07 US disclosed
CN-102421483-B Cosmetic composition comprising a dye, said dye and cosmetic treatment method L'OREAL (FR) 2016-06-01 CN disclosed
US-20140323375-A1 COMBINATION OF AN AMINO ALCOHOL, A FRAGRANCE AND A SILICIC ACID ESTER, AND THE USE OF SAME AS A PRO-FRAGRANCE HENKEL AG & CO. KGAA (DE) 2014-10-30 US disclosed
CN-101617998-B Cosmetic or dermatological composition comprising a compound capable of creating hydrogen bonds, and cosmetic treatment method OREAL FR 2014-06-25 CN disclosed
CN-102421483-A Cosmetic composition comprising a dye, said dye and cosmetic treatment method OREAL 2012-04-18 CN disclosed
CN-101617998-A Cosmetic or dermatological composition comprising a compound capable of creating hydrogen bonds, and cosmetic treatment method OREAL 2010-01-06 CN disclosed
US-20090099382-A1 ACTIVE INGREDIENT CARRIERS WHICH ARE BASED ON SILICON AND CONTAIN AMINOALKYL GROUPS HENKEL AG & CO. KGAA (DE) 2009-04-16 US disclosed
US-7098178-B2 Silicic acid ester mixtures HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 2006-08-29 US disclosed
CN-1767807-A Transparent or translucent care and/or make-up cosmetic composition structured with silicone polymers OREAL (FR) 2006-05-03 CN disclosed
EP-0185526-B1 SOLVENT SOLUBLE FLUORINE-CONTAINING POLYMER, COATING COMPOSITION CONTAINING THE SAME AND COATING PROCESS THEREOF MITSUI SEKIYU KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-03-13 EP disclosed
US-4751114-A COPOLYMER OF FLUOROLEFIN, VINYL ETHER AND ORGANOSILICON COMPOUND MITSUI SEKIYU KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1988-06-14 US disclosed
US-4737444-A UNDERCOATING IS POLYMER CONTAINING METAL ALCOHOLATE RICOH COMPANY, LTD. (JP) 1988-04-12 US disclosed
US-4701508-A ADDITION POLYMER OF FLUOROOLEFIN, A VINYL ETHER UNSATURATED HYDROLYZABLE ESTER OF A SILANEDIOL OR-TRIOL; WEATHERPROOFING; SOLVENT RESISTANCE MITSUI SEKIYU KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1987-10-20 US disclosed
EP-0185526-A2 Solvent soluble fluorine-containing polymer, coating composition containing the same and coating process thereof MITSUI SEKIYU KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1986-06-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099382-A1 ACTIVE INGREDIENT CARRIERS WHICH ARE BASED ON SILICON AND CONTAIN AMINOALKYL GROUPS SMYD2, SCLY, SMYD3 TDP1 1644/4885CA1 2453/4885CA2 2449/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.