Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454008 | 0.81 | OPRM1 (0.40) | OPRM1OPRL1GRM2CYP3A4CYP2E1 | |
| SCHEMBL22771076 | 0.66 | HCAR2 (0.39) | GRM2CYP3A4CYP2C9CYP2C19CHRM2 | |
| SCHEMBL5754953 | 0.66 | CYP3A4 (0.54) | CYP3A4CYP2C9CYP2C19TP53MDM2 | |
| SCHEMBL3408748 | 0.64 | OPRM1 (0.57) | OPRM1OPRL1CYP3A4CHRM2ALDH1A1 | |
| SCHEMBL4484747 | 0.64 | GRM2 (0.39) | GRM2ALDH1A1 | |
| SCHEMBL12533702 | 0.63 | ALDH1A1 (0.46) | OPRM1OPRL1CHRM2TP53MDM2 | |
| SCHEMBL1921153 | 0.63 | ALDH1A1 (0.46) | OPRM1OPRL1CHRM2TP53MDM2 | |
| SCHEMBL1921154 | 0.63 | ALDH1A1 (0.46) | OPRM1OPRL1CHRM2TP53MDM2 | |
| SCHEMBL27668095 | 0.63 | ALDH1A1 (0.46) | OPRM1OPRL1CHRM2TP53MDM2 | |
| SCHEMBL4447358 | 0.62 | ELANE (0.38) | GRM2CYP2C19MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137577-A1 | HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137577-A1 | HETEROCYCLIC COMPOUNDS | CYP2D6, ABCG2, CYP2B6 | OPRM1 507/4885OPRL1 1562/4885GRM2 4432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.