Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.43 |
| ▸ | PNLIP | P16233 | 1/20 | 0.42 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804037 | 0.88 | CYP1A2 (0.59) | EPHX2CYP1A2CYP2C9CYP2C19HTR2A | |
| SCHEMBL15168933 | 0.88 | EPHX2 (0.51) | EPHX2CYP1A2CYP2C9CYP2C19HTR2A | |
| SCHEMBL4855842 | 0.86 | ALDH1A1 (0.55) | EPHX2CYP1A2CYP2C9CYP2C19HTR2A | |
| SCHEMBL23088133 | 0.83 | EPHX2 (0.79) | EPHX2CYP1A2CYP2C9CYP2C19KDR | |
| SCHEMBL28526013 | 0.81 | TDP1 (0.58) | EPHX2CYP1A2CYP2C9CYP2C19HTR2A | |
| SCHEMBL2347463 | 0.81 | EPHX2 (0.49) | EPHX2CYP1A2CYP2C9CYP2C19HTR2A | |
| SCHEMBL28526011 | 0.80 | EPHX2 (0.48) | EPHX2CYP1A2CYP2C9CYP2C19HTR2A | |
| Fluoride SCHEMBL11789657 | 0.80 | EPHX2 (0.54) | EPHX2PNLIPMAPTKMT2AMEN1 | |
| SCHEMBL2635423 | 0.79 | EPHX2 (0.60) | EPHX2CYP1A2CYP2C9CYP2C19KCNK3 | |
| SCHEMBL5914904 | 0.78 | DHODH (0.57) | EPHX2CYP1A2CYP2C9KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558582-B1 | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2005-12-21 | — | — | EP | disclosed |