Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.38 |
| ▸ | APP | P05067 | 14/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445583 | 0.78 | APP (0.35) | BACE1APP | |
| SCHEMBL430320 | 0.68 | APP (0.34) | BACE1APP | |
| Hydrochloric Acid SCHEMBL2390619 | 0.65 | BACE1 (0.40) | BACE1APPKDM1A | |
| SCHEMBL1794485 | 0.65 | PNMT (0.40) | BACE1APPPNMT | |
| SCHEMBL19530386 | 0.64 | BACE1 (0.56) | BACE1APP | |
| SCHEMBL429166 | 0.64 | BACE1 (0.44) | BACE1APP | |
| SCHEMBL445389 | 0.63 | BACE1 (0.65) | BACE1APP | |
| SCHEMBL3346479 | 0.62 | PNMT (0.38) | BACE1APPPNMTKDM1A | |
| SCHEMBL430947 | 0.62 | AKR1B1 (0.43) | BACE1 | |
| SCHEMBL7920039 | 0.62 | PNMT (0.39) | PNMTKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065195-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. | 2012-03-15 | — | — | US | disclosed |
| WO-2011123674-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065195-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | APP, BACE1, PSEN1 | BACE1 2/4885APP 1/4885PNMT 1220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.