Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 4/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794485 | 0.83 | PNMT (0.40) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL18065482 | 0.79 | PNMT (0.38) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL18065483 | 0.79 | PNMT (0.38) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL13344276 | 0.77 | CYP3A4 (0.39) | ADRA2AMETAP1 | |
| SCHEMBL24275671 | 0.76 | TDP2 (0.41) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL7920039 | 0.75 | PNMT (0.39) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL240792 | 0.73 | TDP2 (0.41) | TDP2CMA1AHRMETAP1 | |
| SCHEMBL24424921 | 0.72 | TDP1 (0.43) | PNMTTDP2ASIC3CMA1AHR | |
| SCHEMBL865619 | 0.72 | HTR2A (0.41) | KDM1A | |
| SCHEMBL23811628 | 0.72 | DRD2 (0.45) | ADRA2AADRA2BKDM1AMETAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057865-A1 | N- INDEN- 2 -YL- ISOPROPYLSULFONAMIDES AS AMPA RECEPTOR POTENTIATORS | GLAXO GROUP LIMITED (GB) | 2010-05-27 | — | — | WO | disclosed |