Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 17/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837633 | 0.84 | NR3C1 (0.49) | NR3C1PGRSMO | |
| SCHEMBL4327025 | 0.80 | NR3C1 (0.55) | NR3C1PGRCYP11B1CYP11B2AR | |
| SCHEMBL836751 | 0.78 | CYP11B2 (0.67) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL3814256 | 0.76 | NR3C1 (0.52) | NR3C1PGRSMO | |
| SCHEMBL836675 | 0.74 | NR3C1 (0.65) | NR3C1PGR | |
| SCHEMBL4556584 | 0.74 | NR3C1 (0.72) | NR3C1PGR | |
| SCHEMBL10280432 | 0.74 | NR3C1 (0.72) | NR3C1PGR | |
| SCHEMBL834662 | 0.74 | NR3C1 (0.72) | NR3C1PGR | |
| SCHEMBL4462756 | 0.74 | NR3C1 (0.72) | NR3C1PGR | |
| SCHEMBL4558006 | 0.74 | NR3C1 (0.72) | NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102169-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | AstraZeneca AB (SE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |